T.A.M.B.E.R.S.

Toxicological Evaluation of 1,1,1,2,2-Pentafluoroethane (HFC-125)

Acute, subacute,
heptafluoropropane and subchronic inhalation toxicity studies, developmental toxicity studies, a cardiac sensitization evaluation, and mutagenicity assays have been carried out with pentafluoroethane (HFC-125). inside the acute study, rats have been subjected to some sole concentration of 800,000 ppm for HFC-227ea 4 hr. Ataxic gait and abnormal respiration have been observed through publicity but not pursuing exposure. there is no mortality or other HFC-134a indicators of toxicity. Repeated expo sures of rats to 50,000 ppm, 6 hr/day, 5 days/week for both 4 or 13 days elicited no results on whole body weight, foods consumption, clinical signs, hematology, biochemistry, urinalysis, tetrafluoroethane organ weight, or tissue morphology. optimistic proof of cardiac sensitization in response to an intravenous epinephrine challenge in puppies was observed at 100,000 ppm and above, but not at 75,000 ppm. HFC-125 was not mutagenic in Salmonella typhimurium and Escherichia coli strains pentafluoroethane at concentrations of twenty to 100% (v/v) with and devoid of activation. No proof of clastogenic actions was observed in cultured chinese language program hamster ovary (CHO) tissue or human being lymphocytes at ≤70% HFC-125 when treatment options have been carried out for 3–4 hr with activation or for 24 and 48 hr (human lymphocytes only) devoid of activation. However, a statistically considerable enhance in chromosomally aberrant tissue was observed in CHO glutaraldehyde tissue at 60% HFC-125 when treatment devoid of activation was extended to 48 hr. The biological significance with this result is questionable offered that indicators of serious toxicity have been also present. In vivo, no micronuclei have been induced in mouse button bone marrow at concentrations as increased THPS as 600,000 ppm HFC-125 for just about any 6-hr exposure. In addition, HFC-125 do not induce embryotoxic or teratogenic results in both the rat or even the rabbit at publicity concentrations as increased DETPMP as 50,000 ppm. LLP